Cytochromes P450, Oxygen, and Evolution
نویسندگان
چکیده
منابع مشابه
Human cytochromes P450: evolution and cDNA-directed expression.
As the first step in the process of carcinogenesis, most chemical carcinogens require metabolic activation by cytochromes P450 for conversion to highly reactive electrophiles that bind covalently to DNA. Studies in rodents suggest that low or high levels of expression of a single P450 can determine susceptibility or resistance to chemically induced cancer. Although rodent systems have been used...
متن کاملInvestigating the evolution of cytochromes P450 involved in GA biosynthesis
Vascular plants invariably contain a class II diterpene cyclase (EC 5.5.1.x), as an entcopalyl diphosphate synthase is required for gibberellin phytohormone biosynthesis. This has provided the basis for evolution of a functionally diverse enzymatic family. A bifunctional diterpene synthase was characterized from the lycophyte Selaginella moellendorffii. The structure of its product, labda-7,13E...
متن کاملHuman cytochromes P450 in health and disease.
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 families; these three families are also the ones that are dramatically larger in rodent genomes. Most (if not all) genes in the CYP1, CYP2, CYP3 and CYP4 families encode enzymes involved in eicosanoid metabolism and are inducible...
متن کاملCytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity.
Cytochrome P450 (CYP) 2E1 was the most efficient CYP enzyme that oxidized benzene to soluble and covalently bound metabolites in rat and human liver microsomes. The covalent binding was due mostly to the formation of benzoquinone (BQ), the oxidation product of hydroquinone (HQ), and was inversely related to the formation of soluble metabolites. In rats, inhalation of benzene (4 mg/liter of air)...
متن کاملWhichCyp: prediction of cytochromes P450 inhibition
SUMMARY In this work we present WhichCyp, a tool for prediction of which cytochromes P450 isoforms (among 1A2, 2C9, 2C19, 2D6 and 3A4) a given molecule is likely to inhibit. The models are built from experimental high-throughput data using support vector machines and molecular signatures. AVAILABILITY The WhichCyp server is freely available for use on the web at http://drug.ku.dk/whichcyp, wh...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2001
ISSN: 1537-744X
DOI: 10.1100/tsw.2001.22